An H2S‐Sensing/CO‐Releasing Flavonol That Operates via Logic Gates

Document Type

Article

Journal/Book Title

Chempluschem

Publication Date

12-2017

Publisher

Wiley

Award Number

NIH 1R15GM124596-01

Funder

NIH

Volume

82

Issue

12

First Page

1408

Last Page

1412

Abstract

Signaling molecules, including H2S and CO, are involved in a complex interplay within cells to maintain cellular homeostasis. In order to investigate the intracellular interplay of different gasotransmitters, new molecular tools are needed that combine the sensing and release capabilities of different small molecules in a single, multifunctional, and highly regulated molecular platform. This report gives the first example of a combined H2S‐sensor/CO‐releasing molecule. This flavonol‐based molecular tool operates intracellularly via a highly regulated AND logic gated input–output sequence and provides fluorescent feedback for the H2S detection and CO release steps. This linear sequence can be combined with a fluorescent molecular sensor for CO detection via a third distinct emission. Overall, this is the first molecular framework that can combine the sensing of H2S with the controlled release of CO, two gaseous molecules that are known to exhibit reciprocal regulation and have overlapping targets in cellular environments.

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