Comment on "Structural Evidence for a Dynamic Metallocofactor During N₂ Reduction by Mo-Nitrogenase"

Authors

John W. Peters, Washington State University Pullman
Oliver Einsle, Universität Freiburg
Dennis R. Dean, Virginia Polytechnic Institute and State University
Serena DeBeer, Max Planck Institute for Chemical Energy Conversion
Brian M. Hoffman, Northwestern University
Patrick L. Holland, Yale University
Lance C. Seefeldt, Utah State UniversityFollow

Document Type

Article

Journal/Book Title

Science

Publication Date

2-12-2021

Publisher

American Association for the Advancement of Science (AAAS)

Volume

371

Issue

6530

First Page

1

Last Page

3

Abstract

Kang et al. (Reports, 19 June 2020, p. 1381) report a structure of the nitrogenase MoFe protein that is interpreted to indicate binding of N2 or an N2-derived species to the active-site FeMo cofactor. Independent refinement of the structure and consideration of biochemical evidence do not support this claim.

Recommended Citation

Peters, J. W., Einsle, O., Dean, D. R., DeBeer, S., Hoffman, B. M., Holland, P. L., and Seefeldt, L. C. (2021) Comment on “Structural evidence for a dynamic metallocofactor during N2 reduction by Mo-nitrogenase.” Science 371, eabe5481.