A patient who repeatedly produced urinary calculi, had consumed about 3g of cristobalite (SiO2) per day for many years. Investigations using scanning electron microscopy revealed minute particles containing silicon in the core of the stone as well as in urine sediment. A mechanism similar to that proposed for the effect of silicon-containing drugs against gastric ulcer, may play a role in this formation of silicon-containing urinary stones.
Leusmann, D. B.; Pohl, J.; and Kleinhans, G.
"Urolithiasis in a Patient Ingesting Pure Silica: A Scanning Electron Microscopy Study,"
Scanning Electron Microscopy: Vol. 1986
, Article 44.
Available at: https://digitalcommons.usu.edu/electron/vol1986/iss2/44