Date of Award:

1984

Document Type:

Dissertation

Degree Name:

Doctor of Philosophy (PhD)

Department:

Chemistry and Biochemistry

Department name when degree awarded

Toxicology Graduate Program

Advisor/Chair:

R. P. Sharma

Abstract

3,5,6-trichloro-2-pyridinol, when administered in the diet, increases the feed efficiency (the ratio of weight gain to feed consumed) in various species of domestic animals and also appears to be retained in the liver at low concentrations, possibly by binding to a specific macromolecule. Because of its structural similarities to the outer ring of the thyroid hormones, trichloropyridinol and three structural analogs (2,4,5-trichlorophenol, 4-bromo-2,5- dichlorophenol, or 4-i odo-2,5-dichlorophenol) were tested for ability to compete in vitro with 3, 5, 3' -triiodothyronine (T ) for nuclear recept ors specific for the thyroid hor- 3 manes . All four of the halogenated compounds were found to be weakly competitive for the receptor, indicating a passible anti-thyroid effect.

Weanling male rats were fed diets containing 5, 50, and 500 ppm trichloropyridinol for 30, 60, and 90 days. Other groups received a diet containing 200 and 2000 ppm 2-thiouracil, a known thyroid toxicant. Both chemicals significantly reduced serum thyroxine (T4) levels in a dose-related manner. It was of interest that trichloropyridinol was about as levels. potent Serum T3 as thiouracil in suppressing serum T 4 and 3,3'5'-triiodothyronine (rT3) levels were depressed by thiouracil, but generally not with trichloropyridinol. Nuclear T binding capacity was not 3 changed in the liver of rats ingesting trichloropyridinol. Body weight, feed efficiency, and organ weights and histology were not significantly altered by the chronic ingestion of trichl oropyridinol.

In conclusion, the effects trichloropyridinol upon animal growth and feed efficiency may involve various mechanisms surrounding thyroid hormone expression including reduction of serum T4 levels and competition with T3 for the nuclear receptor.

Included in

Toxicology Commons

Share

COinS