Date of Award:


Document Type:


Degree Name:

Doctor of Philosophy (PhD)


Animal, Dairy, and Veterinary Sciences

Department name when degree awarded


Committee Chair(s)

Joseph T. Blake


Joseph T. Blake


Thomas Bahler


James Gessaman


James Shupe


Donald Sisson


Twenty four cattle, six each of healthy cows and calves, and cows and calves with brisket disease, were obtained, examined and slaughtered. The concentrations of calcium, chloride, cobalt, copper, iron, magnesium, molybdenum, phosphorus, potassium, sodium and zinc; and percent absolute dry matter and percent ash were determined in tissues selected from the following: cardiac, hepatic, renal, osseous, whole blood and blood serum. In addition, certain physical and biological parameters were recorded for each animal. The results were analyzed as a 2 x 2 factorial, segregating the effects of age and brisket disease, and the age-disease interaction.

The following statistically significant (P

The effects of brisket disease are superimposed upon these marked differences in the cattle in the present study as compared to those in a previous study of well nourished cattle of similar breeding from a similar environment: reduced cardiac, hepatic, serum and osseous calcium; reduced hepatic, osseous and serum magnesium and increased renal magnesium; reduced hepatic phoshporus and increased renal phosphorus; reduced hepatic, serum and osseous potassium and increased cardiac potassium; and reduced cardiac, osseous and serum sodium and zinc.

The effects of age must be evaluated in view of the fact that half of the animals were diseased; moreover, some age effects occurred almost exclusively in the diseased animals. Statistically significant (P

The interaction of increased age and brisket disease produced the following statistically significant (P

Hypotheses regarding possible reasons for these results are formulated and discussed.



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