Date of Award:
Master of Science (MS)
Department name when degree awarded
Carl D. Cheney
Rats given L-Ascorbic Acid in their drinking water prior to and during starvation did not develop severe ulceration in the glandular portion of their stomachs. Control rats which were either nontreated or given deactivated L-Ascorbic Acid developed severe stomach pathology on the starvation regimen.
The present study was based on the finding that food deprivation results in severe rumenal ulceration in rats. Given that L-AA is essential in maintaining tissue integrity and that ulcers are examples of tissue degeneration, the L-AA in large amounts could retard, or prevent, the formation of starvation induced stomach ulcers in rats.
The results show that large amounts of active L-AA were beneficial in maintaining the integrity of rat gastrointestinal tissue exposed to starvation conditions which, in the vitaimin's absence, induces deterioration.
Rudrud, Eric H., "The Production and Prevention of Stomach Ulcers in Rodents" (1974). All Graduate Theses and Dissertations. 5763.
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