Date of Award:
12-2019
Document Type:
Thesis
Degree Name:
Master of Science (MS)
Department:
Chemistry and Biochemistry
Committee Chair(s)
Cheng-Wei Tom Chang
Committee
Cheng-Wei Tom Chang
Committee
Alvan C. Hengge
Committee
Robert S. Brown
Abstract
The synthesis of 3- and 6- aminosugars from the old route requires many synthetic steps and is challenging. An alternative approach is to utilize acid-catalyzed hydrolysis of kanamycin derivatives. The 3-and 6 aminosugar donor was synthesized in just two steps with excellent yield and cost-effective. The acidic hydrolysis of these aminoglycosides provided not only the 3-and 6-aminosugars, but the direct chemical glycosylation of these aminosugars was proven feasible using isopropanol and octanol as the acceptor.
Checksum
582699672cfda92e7de9cc8e546431c1
Recommended Citation
Pandey, Uddav, "An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach" (2019). All Graduate Theses and Dissertations, Spring 1920 to Summer 2023. 7692.
https://digitalcommons.usu.edu/etd/7692
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