Date of Award:
Master of Science (MS)
Chemistry and Biochemistry
Cheng-Wei Tom Chang
Alvan C. Hengge
Robert S. Brown
The synthesis of 3- and 6- aminosugars from the old route requires many synthetic steps and is challenging. An alternative approach is to utilize acid-catalyzed hydrolysis of kanamycin derivatives. The 3-and 6 aminosugar donor was synthesized in just two steps with excellent yield and cost-effective. The acidic hydrolysis of these aminoglycosides provided not only the 3-and 6-aminosugars, but the direct chemical glycosylation of these aminosugars was proven feasible using isopropanol and octanol as the acceptor.
Pandey, Uddav, "An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach" (2019). All Graduate Theses and Dissertations. 7692.
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