Vascular Changes in Popliteal Lymph Nodes due to Antigen Challenge in Normal and Lethally Irradiated Mice

Authors

Douglas A. Steeber, University of Wisconsin
Chris M. Erickson, University of Wisconsin
Kees C. Hodde, Amsterdam Medical Center
Ralph M. Albrecht, University of Wisconsin

Abstract

The microvascular system of the murine popliteal lymph node was investigated using scanning electron microscopy of microcorrosion casts. Time-dependent changes in the microvasculature following regional antigen challenge in normal and lymphocyte-depleted mice were studied. Normal lymph node microvasculature exhibited a significant increase in both the vascular bed and post-capillary venules containing high-endothelium in response to antigen challenge. Lymph nodes of lymphocyte-depleted mice showed no microvascular size increase following antigen challenge and a reduction in the amount of high-endothelium was observed.

Recommended Citation

Steeber, Douglas A.; Erickson, Chris M.; Hodde, Kees C.; and Albrecht, Ralph M. (1987) "Vascular Changes in Popliteal Lymph Nodes due to Antigen Challenge in Normal and Lethally Irradiated Mice," Scanning Microscopy: Vol. 1: No. 2, Article 41.
Available at: https://digitalcommons.usu.edu/microscopy/vol1/iss2/41