Surface Heterogeneity of Tumor Cells and Changes Upon Ionizing Radiation

Authors

Z. Somosy, "Frédéric Joliot-Curie"National Research Institute for Radiobiology and Radiohygiene
Orsolya Csuka, National Institute of Oncology
Tamara Kubasova, "Frédéric Joliot-Curie"National Research Institute for Radiobiology and Radiohygiene
J. Kovács, Eötvös Lorand University
G. J. Köteles, "Frédéric Joliot-Curie"National Research Institute for Radiobiology and Radiohygiene

Abstract

Heterogeneous distribution of surface domains is a characteristic feature of the tumor cell surface and the distribution differs from that of normal cells. During the malignant transformation the heterogeneity may change or disappear. Cell lines with various metastasizing capacities show different distributions of membrane domains or other differences in membrane or surface organization. We have demonstrated that the amount and distribution of negatively charged sites of B 16 melanoma membranes changed upon ionizing radiation (X-ray, ⁶⁰Co-gamma). In the case of the P 388 lymphoma, however, only the amount of negatively charged sites change after irradiation, the distribution remains unaltered. Both features proved to be radioresistant in human lymphoid leukemic cells.

Recommended Citation

Somosy, Z.; Csuka, Orsolya; Kubasova, Tamara; Kovács, J.; and Köteles, G. J. (1989) "Surface Heterogeneity of Tumor Cells and Changes Upon Ionizing Radiation," Scanning Microscopy: Vol. 3: No. 3, Article 21.
Available at: https://digitalcommons.usu.edu/microscopy/vol3/iss3/21