Title

Bioavailability to Anemic Rats of Iron from Fresh, Cooked, or Nitrosylated Hemoglobin and Myoglobin

Document Type

Article

Journal/Book Title/Conference

Journal of Nutrition

Volume

113

Issue

3

Publication Date

1983

First Page

680

Last Page

687

Abstract

Bioavailabilities of heme iron prepared from lyophilized, fresh, cooked, nitrosylated hemoglobin and purified myoglobin in semipurified diets were investigated in two experiments. In experiment 1, the bioavailabilites of porcine and bovine hemoglobins were about one-third that for ferrous sulfate regardless of hemoglobin treatments. The efficiency of hemoglobin regeneration by anemic rats fed nitrosylated pork hemoglobin was significantly depressed compared with that by those fed unnitrosylated products. Cooking did not affect the availability of the heme iron, whereas washing tended to increase it. In experiment 2, the hemoglobin regeneration efficiency of the purified myoglobin diet was lower than reported by others for meat diets, and was even lower than that of the purified hemoglobin diet. The respective efficiency values for the basal, basal + FeSO4, hemoglobin, and myoglobin diets (experiment 2) were 0.073, 0.581, 0.199, and 0.125. The efficiencies of converting hemoglobin and ferrous sulfate iron into hemoglobin by the anemic rats were very similar to reported absorption values for these iron sources by iron-deficient human subjects.

Comments

Originally published by The American Society for Nutrition. Abstract and full text available via remote link.