In vitro Antioxidant Treatment Model for Oxidative Stress in Simulated Microgravity
Class
Article
Graduation Year
2017
College
College of Engineering
Department
Biological Engineering Department
Faculty Mentor
Dr. Elizabeth Vargis
Presentation Type
Oral Presentation
Abstract
Muscular atrophy, or loss of muscle mass, is prevalent when muscle use is limited by immobilization on earth, or in microgravity when muscle tissue is not exercised by regular loading. Oxidative stress increases with limited muscle use and as astronauts are exposed to ionizing radiation during space travel. This oxidative stress kills muscles cells, causing even further breakdown of the tissue and damage to DNA, increasing cancer risk. We propose that by introducing a variety of antioxidants to combat oxidative stress on murine C2C12 muscle cells that muscular atrophy, ionizing radiation damage, and cell death can be greatly a reduced.
Location
Room 154
Start Date
4-13-2017 3:00 PM
End Date
4-13-2017 4:15 PM
In vitro Antioxidant Treatment Model for Oxidative Stress in Simulated Microgravity
Room 154
Muscular atrophy, or loss of muscle mass, is prevalent when muscle use is limited by immobilization on earth, or in microgravity when muscle tissue is not exercised by regular loading. Oxidative stress increases with limited muscle use and as astronauts are exposed to ionizing radiation during space travel. This oxidative stress kills muscles cells, causing even further breakdown of the tissue and damage to DNA, increasing cancer risk. We propose that by introducing a variety of antioxidants to combat oxidative stress on murine C2C12 muscle cells that muscular atrophy, ionizing radiation damage, and cell death can be greatly a reduced.