Applying Pharmacokinetic and Pharmacodynamic Models in the Operating Room: Validation of Response Surface Models
Description
Pharmacokinetics are used to model drug concentrations in the body. These predictions can be combined with pharmacodynamic response surface models that predict the effect of multiple drugs acting on the body. This study combined several pharmacokinetic and pharmacodynamic models to predict “adequate anesthesia.” These predictions were compared to observations in patients. While these specific model combinations are not accurate predictors of anesthesia for the recovery of responsiveness and tracheal intubation, a few combinations are reasonable predictors of the loss of responsiveness and also for the analgesia necessary for the first skin incision. The Schnider propofol model and a fentanyl scaling factor of 1.2 are empirically the most accurate PK models in combination with the pharmacodynamic models used.
Applying Pharmacokinetic and Pharmacodynamic Models in the Operating Room: Validation of Response Surface Models
Salt Lake Community College
Pharmacokinetics are used to model drug concentrations in the body. These predictions can be combined with pharmacodynamic response surface models that predict the effect of multiple drugs acting on the body. This study combined several pharmacokinetic and pharmacodynamic models to predict “adequate anesthesia.” These predictions were compared to observations in patients. While these specific model combinations are not accurate predictors of anesthesia for the recovery of responsiveness and tracheal intubation, a few combinations are reasonable predictors of the loss of responsiveness and also for the analgesia necessary for the first skin incision. The Schnider propofol model and a fentanyl scaling factor of 1.2 are empirically the most accurate PK models in combination with the pharmacodynamic models used.