Event Title

Model-Based Propofol Dosing to Improve Control of Patient EEG Dynamics

Location

Room # EB402

Start Date

5-6-2019 11:10 AM

Description

Propofol is a common anesthetic, which is being investigated as an antidepressant alternative to electroconvulsive therapy (ECT). Propofol can induce similar EEG effects to that of ECT, and has also demonstrated similar improvements in depression scores. However, propofol dosing is challenging because patients differ in their required drug doses. A model of the relationship between administered propofol and monitored EEG can be used to improve the accuracy and reliability of this treatment. Our objective is ultimately to automate processes in propofol’s dose determination. A summary of patient-system modeling in anesthesia will be discussed, along with preliminary results from recent open-label trials.

Comments

Session 4

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May 6th, 11:10 AM

Model-Based Propofol Dosing to Improve Control of Patient EEG Dynamics

Room # EB402

Propofol is a common anesthetic, which is being investigated as an antidepressant alternative to electroconvulsive therapy (ECT). Propofol can induce similar EEG effects to that of ECT, and has also demonstrated similar improvements in depression scores. However, propofol dosing is challenging because patients differ in their required drug doses. A model of the relationship between administered propofol and monitored EEG can be used to improve the accuracy and reliability of this treatment. Our objective is ultimately to automate processes in propofol’s dose determination. A summary of patient-system modeling in anesthesia will be discussed, along with preliminary results from recent open-label trials.