Document Type

Article

Journal/Book Title/Conference

Journal of Infectious Diseases

Volume

216

Issue

10

Publisher

Oxford University Press

Publication Date

12-16-2017

First Page

S919

Last Page

S927

Abstract

Zika virus (ZIKV) infection can result in serious consequences, including severe congenital manifestations, persistent infection in the testes and neurologic sequelae. After a pandemic emergence, the virus has spread to much of the new world and has been introduced to many countries outside of endemic areas as infected travelers return to their home countries. Rodent models have been important in gaining a better understanding of the wide range of disease etiologies associated with ZIKV infection and for the initial phase of developing countermeasures to prevent or treat viral infections. We discuss herein the advantages and disadvantages of small animal models that have been developed to replicate various aspects of disease associated with ZIKV infection.

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