Title

Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model

Document Type

Article

Journal/Book Title/Conference

Antimicrobial Agents and Chemotherapy

Volume

48

Issue

6

Publisher

American Society for Microbiology

Publication Date

2004

First Page

2318

Last Page

2320

DOI

10.1128/AAC.48.6.2318-2320.2004

Abstract

ORI-9020, a novel dinucleotide, evaluated in transgenic mice expressing hepatitis B virus (HBV), significantly reduced liver HBV DNA (P <= 0.001). Levels of HBeAg and HBsAg in serum and of HBcAg in liver were not affected by treatment. A minimal effective dosage was determined to be between 1.6 and 0.5 mg/kg of body weight/day, which was similar to that observed for adefovir dipivoxil.