(–)-Carbodine: Enantiomeric Synthesis and in Vitro Antiviral Activity Against Various Strains of Influenza Virus Including H5N1 (Avian Influenza) and Novel 2009 H1N1 (Swine Flu)

Authors

J. R. Rao
A. K. Jha
R. K. Rawal
A. Sharon
C. W. Day
Dale L. Barnard, Utah State UniversityFollow
Donald F. Smee, Utah State UniversityFollow
C. K. Chu

Document Type

Article

Journal/Book Title/Conference

Carbodine: enantiomeric synthesis and in vitro antiviral activity againstvarious strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1(swine flu)

Volume

20

Publication Date

2010

First Page

2601

Last Page

2604

Abstract

Enantiomerically pure cyclopentyl cytosine [(−)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (±)-carbodine and ribavirin. (−)-Carbodine 1 exhibited potent antiviral activity against various strains of influenza A and B viruses.

Comments

Bioorg. Med. Chem. Lett. 20:2601-2604. PMID: 20231094

Recommended Citation

Rao, J.R., Jha, A.K., Rawal, R.K., Sharon, A., Day, C.W., Barnard, D.L., Smee, D.F., Chu, C.K. 2010. (-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu). Bioorg. Med. Chem. Lett. 20:2601-2604. PMID: 20231094