Document Type
Article
Journal/Book Title/Conference
Induction of IP-10 by SARS-CoV infection of Calu-3cells and BALB/c mice
Volume
20
Publisher
International Medical Press
Publication Date
2010
First Page
169
Last Page
177
Abstract
Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated inflammation associated with the recruitment of immune responses. The presence of antigenically disparate pulmonary viruses and the emergence of novel viruses assures the recurrence of lung damage with infection and resolution of each primary viral infection. Thus, there is a need to develop safe broad spectrum immunoprophylactic strategies capable of enhancing protective immune responses in the lung but which limits immune-mediated lung damage. The immunoprophylactic strategy described here utilizes a protein cage nanoparticle (PCN) to significantly accelerate clearance of diverse respiratory viruses after primary infection and also results in a host immune response that causes less lung damage.
Recommended Citation
Kumaki, Y., Day, C.W., Bailey, K.W., Wong, M.-H., Wandersee, M.K., Madsen, R., Madsen, J.S., Nelson, N.M., Hoopes, J.D, Woolcott, J.D., McLean, Z.T., Blatt, L.M., Salazar, A.M., Barnard, D.L.* 2010. Induction of IP-10 by SARS-CoV infection of Calu-3 cells and BALB/c mice. Antivir. Chem. Chemother. 20:169-177. PMID: 20231782
Comments
Originally published by International Medical Press. Publisher's PDF available through remote link.
http://www.intmedpress.com/index.cfm?pid=16