Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs
Document Type
Article
Journal/Book Title/Conference
Bioorganic & Medicinal Chemistry Letters
Volume
20
Publication Date
2010
First Page
1783
Last Page
1786
Abstract
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).
Recommended Citation
Coughlin, J. E., S. Padmanabhan, G. Zhang, C. J. Kirk, C. P. Govardhan, B. E. Korba, K. O'Loughlin, C. E. Green, J. Mirsalis, J. D. Morrey, and R. P. Iyer. 2010. Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs. Bioorg Med Chem Lett 20:1783-1786. PMID20117930 PMCPMC2826611
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