The Use of Isotopes in the Study of Reactions of Acyl, Phosphoryl,and Sulfuryl Esters

Document Type

Article

Journal/Book Title

Journal of Labelled Compounds and Radiopharmaceuticals

Publication Date

2007

Volume

50

First Page

1026

Last Page

1038

Abstract

Acyl, phosphoryl, and sulfuryl transfer reactions involving esters and amides are ubiquitous in the biochemical world, and these reactions are found throughout the biochemical pathways involving proteins, nucleic acids, and other compounds essential for life. Such compounds are also common in commercial chemical processes. The use of isotopes has contributed greatly to our understanding of the chemistry of these compounds. There is an enormous body of literature on the use of isotopes in such studies, and this review does not do justice to this great body of knowledge. We cover a selection of reactions for which multiple experimental applications using isotopes have been used in the advancement of mechanistic studies.

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