The Use of Isotopes in the Study of Reactions of Acyl, Phosphoryl,and Sulfuryl Esters
Document Type
Article
Journal/Book Title
Journal of Labelled Compounds and Radiopharmaceuticals
Publication Date
2007
Volume
50
First Page
1026
Last Page
1038
Abstract
Acyl, phosphoryl, and sulfuryl transfer reactions involving esters and amides are ubiquitous in the biochemical world, and these reactions are found throughout the biochemical pathways involving proteins, nucleic acids, and other compounds essential for life. Such compounds are also common in commercial chemical processes. The use of isotopes has contributed greatly to our understanding of the chemistry of these compounds. There is an enormous body of literature on the use of isotopes in such studies, and this review does not do justice to this great body of knowledge. We cover a selection of reactions for which multiple experimental applications using isotopes have been used in the advancement of mechanistic studies.
Recommended Citation
R. H. Hoff and A. C. Hengge. “The Use of Isotopes in the Study of Reactions of Acyl, Phosphoryl, and Sulfuryl Esters,” Journal of Labelled Compounds and Radiopharmaceuticals, 2007; 50, 1026- 1038.