Modifying Dementia Risk and Trajectories of Cognitive Decline in Aging: The Cache County Memory Study

Authors

Kathleen A. Welsh-Bohmer, Duke University Medical Center
John C. S. Breitner, University of Washington School of Medicine
Kathleen M. Hayden, Duke University Medical Center
Constantine Lyketsos, John Hopkins University School of Medicine
Peter P. Zandi, Johns Hopkins Bloomberg School of Public Health
JoAnn T. Tschanz, Utah State UniversityFollow
Maria C. Norton, Utah State UniversityFollow
Ronald G. Munger, Utah State UniversityFollow

Document Type

Article

Journal/Book Title/Conference

Alzheimer's & Dementia

Volume

2

Issue

3

Publisher

Elsevier

Publication Date

2006

First Page

257

Last Page

260

Abstract

The Cache County Study of Memory, Health, and Aging, more commonly referred to as the “Cache County Memory Study (CCMS)” is a longitudinal investigation of aging and Alzheimer’s disease (AD) based in an exceptionally long-lived population residing in northern Utah. The study begun in 1994 has followed an initial cohort of 5,092 older individuals (many over age 84) and has examined the development of cognitive impairment and dementia in relation to genetic and environmental antecedents. This article summarizes the major contributions of the CCMS towards the understanding of mild cognitive disorders and AD across the lifespan, underscoring the role of common health exposures in modifying dementia risk and trajectories of cognitive change. The study now in its fourth wave of ascertainment illustrates the role of population-based approaches in informing testable models of cognitive aging and Alzheimer’s disease.

Comments

Originally published by Elsevier. Publisher's PDF and HTML fulltext available through remote link.

Recommended Citation

Welsh-Bohmer KA, Breitner JCS, Hayden KM, Lyketsos C, Zandi PP, Tschanz JT, Norton MC, Munger R. Modifying dementia risk and trajectories of cognitive decline in aging: The Cache County Memory Study. Alzheimer's & Dementia 2006;2:257-260.