Experimental Disease Models of Influenza Virus Infections: Recent Developments

Authors

R. W. Sidwell, Utah State University
Donald F. Smee, Utah State UniversityFollow

Document Type

Article

Journal/Book Title/Conference

Drug Discovery Today: Disease Models

Volume

1

Issue

1

Publisher

Elsevier

Publication Date

2004

First Page

57

Last Page

63

Abstract

Influenza continues to be an important public health threat, and a need continues for models in which the disease, its prevention and treatment modalities can be studied. New colorimetric assay procedures, use of modified viral neuraminidase assays, branched DNA technology for quantifying the negative strand RNA of the viral gene, and polarity-specific viral RNA are among the in vitro assays considered. Studies in mice have focused on models of virus-induced encephalopathies, new disease parameters, and immunosuppression. Significant in vitro and in vivo models of influenza virus infection reported in the past two years are reviewed.

Comments

Originally published by Elsevier. Publisher's PDF and HTML fulltext available through remote link.

Recommended Citation

Sidwell, R.W. and D.F. Smee 2004. Experimental disease models of influenza virus infections: recent developments. Drug Disc. Today: Dis. Models 1: 57-63.