Diurnal Alterations of Catecholamines, Indoleamines and Their Metabolites in Specific Brain Regions of the Mouse
Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology
1. The diurnal variations of regional brain concentrations of dopamine (DA), norepinephrine (NE), serotonin (5-HT) and metabolites were determined in unperturbed male CD-1 mice. Determinations were made every 4 hr for 24 hr. 2. The most striking and significant variations in biogenic amines were seen in the hypothalamus, where concentrations of NE, DA and 5-HT varied in a rhythmic pattern and as much as two-fold during this period. 3. In some cases, daily alterations in parent biogenic amines were reflected by concurrent changes in their metabolites. 4. Since concentrations of neurotransmitters in the brain are often used as an indicator of stress and/or toxicity, these data should provide an accurate data base allowing for more accurate interpretation of results.
Huie, J.M., R.P. Sharma and R.A. Coulombe. (1989). Diurnal alterations of catecholamines and indoleamines and their metabolites in specific regions of the mouse. Comp. Biochem. Physiol. 94C: 575-579.