Title

Anti-humancytomegalovirus activity and toxicity of sulfonated anthraquinones and anthraquinonederivatives

Document Type

Article

Journal/Book Title/Conference

Anti-humancytomegalovirus activity and toxicity of sulfonated anthraquinones and anthraquinonederivatives

Volume

28

Publication Date

1995

First Page

317

Last Page

329

Abstract

Sulfonated anthraquinones and other anthraquinone derivatives were evaluated for anti-human cytomegalovirus (HCMV) activity, cytotoxicity and genotoxicity. Acid blues 40 and 129, acid black 48, alizarin violet R and reactive blue 2 were the most active compounds having selective indices of greater than 30 and ECs0 values of 4-30 p.M. When tested against a clinical isolate, the 4 compounds were 2- to 5-fold less active. The antiviral activity was distinctly separate from the virucidal activity (> 1000 /zM). The compounds were weakly toxic to either log phase or stationary cells in most of the following cytotoxicity assays: neutral red uptake assay, lactic acid dehydrogenase assay, trypan blue exclusion assay and radiolabeled macromolecular precursor uptake assays. Using a genotoxicity assay, the comet assay, only reactive blue 2 and acid black 48 were found to cause DNA strand breakage. This occurred at concentrations of 30 and 170 /zM, respectively. These results suggest that these compounds could be a prototype for synthesizing even more effective HCMV-inhibitory anthraquinone derivatives.

Comments

Antiviral Res. 28: 317-329. PMID: 8669891

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