The Cytochrome P4501A5 Gene in the Turkey (Meleagris gallopavo)
Document Type
Conference Paper
Journal/Book Title/Conference
Proceedings of the 30th International Conference on Animal Genetics ISAG 2006
Publisher
International Society for Animal Genetics
Location
Porto Seguro, Brazil
Publication Date
2006
First Page
52
Last Page
52
Abstract
The Cytochrome P450 gene (CYP1A5) encodes the primary protein responsible for epoxidation of the mycotoxin aflatoxin B1 (AFB1) in the turkey. Hypersensitivity of turkeys to AFB1 was associated with “Turkey X Disease” which caused widespread deaths of turkeys and other poultry throughout Europe in the 1960s. Comparative genomic approaches were used to selectively amplify and sequence the introns and 3’flanking region of CYP1A5. A single nucleotide polymorphism in the 3’UTR was used to genetically map CYP1A5 to turkey linkage group M16. The results of this study provide the framework for identifying allelic variants of this biochemically important P450 gene in poultry.
Recommended Citation
Reed, K.M. and R.A. Coulombe, Jr. The Cytochrome P4501A5 gene in the turkey (Meleagris gallopavo). Presented at the International Society for Animal Genetics conference, Porto Seguro, Brazil, August, 2006.
Comments
Originally published by the International Society for Animal Genetics. PDF containing abstracts from 2006 conference proceedings available through remote link.