Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs
Bioorganic & Medicinal Chemistry Letters
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).
Coughlin, J. E., S. Padmanabhan, G. Zhang, C. J. Kirk, C. P. Govardhan, B. E. Korba, K. O'Loughlin, C. E. Green, J. Mirsalis, J. D. Morrey, and R. P. Iyer. 2010. Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs. Bioorg Med Chem Lett 20:1783-1786. PMID20117930 PMCPMC2826611