Energy Expenditure Across Immune Challenge Severities in a Lizard: Consequences for Innate Immunity, Locomotor Performance and Oxidative Status

Creators

Susannah S. French, Utah State UniversityFollow
Spencer Hudson, Utah State UniversityFollow

Description

Reptiles, like other vertebrates, rely on immunity to defend themselves from infection. The energetic cost of an immune response is liable to scale with infection severity, prompting constraints on other selfmaintenance traits if immune prioritization exceeds energy budget. In this study, adult male side-blotched lizards (Uta stansburiana) were injected with saline (control) or high (20 μg g−1 body mass) or low (10 μg g−1 body mass) concentrations of lipopolysaccharide (LPS) to simulate bacterial infections of discrete severities. The costs and consequences of the immune response were assessed through comparisons of change in resting metabolic rate (RMR), energy metabolites (glucose, glycerol, triglycerides), innate immunity (bactericidal ability), sprint speed and oxidative status (antioxidant capacity, reactive oxygen metabolites). High-LPS lizards had the lowest glucose levels and greatest sprint reductions, while their RMR and bactericidal ability were similar to those of control lizards. Low-LPS lizards had elevated RMR and bactericidal ability, but glucose levels and sprint speed changes between those of high-LPS and control lizards. Levels of glycerol, triglycerides, reactive oxygen metabolites and antioxidant capacity did not differ by treatment. Taken together, energy expenditure for the immune response varies with challenge severity, posing consequences for self-maintenance processes in a reptile.

Author ORCID Identifier

Susannah French https://orcid.org/0000-0001-8923-9728

Spencer Hudson https://orcid.org/0000-0003-1806-8188

Document Type

Dataset

DCMI Type

Dataset

File Format

.csv

Publication Date

8-30-2021

Funder

NSF, Division of Integrative Organismal Systems (IOS)

Publisher

Utah State University

Award Number

NSF, Division of Integrative Organismal Systems (IOS) 1350070

Award Title

CAREER: Physiological Trade-offs in Ecoimmunology: Costs for Individuals and Populations

Methodology

See ReadMe file.

Scientfic Names

Uta stansburiana

Referenced by

Lopes, P. C., French, S. S., Woodhams, D. C., & Binning, S. A. (2021). Sickness behaviors across vertebrate taxa: Proximate and ultimate mechanisms. Journal of Experimental Biology, 224(9), jeb225847. https://doi.org/10.1242/jeb.225847

Location

1559 meters in elevation

Language

eng

Code Lists

See ReadMe File.

Disciplines

Biology

License

This work is licensed under a Creative Commons Attribution 4.0 License.

Identifier

https://doi.org/10.26078/XDTJ-R102

Recommended Citation

French, S., & Hudson, S. (2021). Energy Expenditure Across Immune Challenge Severities in a Lizard: Consequences for Innate Immunity, Locomotor Performance and Oxidative Status [Data set]. Utah State University. https://doi.org/10.26078/XDTJ-R102

Checksum

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