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Proteinases as potential targets for new generation anti-sapstain chemicals

Document Type

Article

Journal/Book Title/Conference

Forest Products Journal

Volume

47

Issue

9

Publisher

Forest Products Society

First Page

57

Last Page

62

Publication Date

9-1997

Abstract

Disrupting nitrogen acquisition by targeted chemicals is a potential strategy for controlling fungal growth of sapstaining fungi in wood. Detailed analyses of pine and aspen sapwood confirmed that very little of the limited available nitrogen is inorganic. Since proteins are the primary nitrogen source in wood, and proteolyte activity was detected in wood infected with the staining fungus Ophiostoma piceae, proteinase inhibitors were tested for their effect on fungal growth. Heavy metals and several chelators inhibited growth on artificial media containing protein or inorganic nitrogen, suggesting that they were toxic to the fungus rather than specific to the proteinase. However, chymostatin, hen egg white, and the commercial sapstain control product PQ-8 appeared to be specific proteinase inhibitors, because they caused a decrease in growth on a protein-supplemented medium that induces proteinase production, but had little effect on growth in a medium containing inorganic nitrogen.

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