Document Type
Article
Journal/Book Title
Phytochemistry Letters
Publication Date
5-4-2020
Publisher
Elsevier BV
Volume
37
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Abstract
In this work we report the isolation, identification and antibacterial activity of two anthraquinones, 2-hydroxy-1-methoxyanthraquinone (1) and 2,5-dihydroxy-1-methoxy-6-methoxymethylanthraquinone (2), from the stem bark of Morinda lucida. These two natural products were selectively converted into two new glycosylated derivatives, 2-hydroxy-1-methoxyanthraquinone-4′-O-methyl-2-O-β-d-glucopyranoside (3) and 2,5-dihydroxy-1-methoxy-6-methoxymethylanthraquinone-4′-O-methyl-2-O-β-d-glucopyranoside (4) by the filamentous fungus Beauveria bassiana ATCC 7159. Structure elucidation was accomplished based on the 1D and 2D NMR, IR and mass spectra. The glycosylated compounds 3 and 4 showed higher in vitro antibacterial activity against Salmonella enterica subsp. enterica sérovars Typhimurim (MIC of 8 μg/mL each) than the corresponding aglycons 1 and 2 (MIC of 16 μg/mL and 32 μg/mL, respectively). These results indicated that microbial glycosylation is an effective approach to modify natural products for enhanced biological activities.
First Page
1
Last Page
21
Recommended Citation
Mfonku, N. A., Mbah, J. A., Kodjio, N., Gatsing, D., & Zhan, J. 2020. Morinda lucida, Anthraquinones, Beauveria bassiana, Microbial biotransformation, 4'-O-Methylglycosylation, Antibacterial activity. Phytochemistry Letters. https://doi.org/10.1016/j.phytol.2020.04.011
