Journal Water Pollution Control Federation
Current development and use of short-term bioassays to evaluate potential human health hazards of environmental chemical exposure has been the focus of the U. S. Environmental Protection Agency (EPA) Second and Third Symposia on the Ap plication of Short-Term Bioassays in the Analysis of Complex Environmental Mixtures.1'2 Topics addressed included development and applications of bioassays, collection and preparation of environmental samples, characterization of hazardous components using bioassays, and environmental assessment. Bartsch and Tomabis,3 using six mutagenicity assays including sub mammalian and mammalian assays to evaluate the quantitative relationship between carcinogenicity and mutagenicity for 532 chemicals, concluded that development and application of a battery of short-term tests can significantly contribute to pre diction of carcinogenic effects of chemicals in man.
Sims, Ronald C.; Sims, J. L.; and Dupont, R. R., "Human Health Effects Assays" (1984). Biological Engineering Faculty Publications. Paper 63.