Document Type
Poster
Journal/Book Title/Conference
College of Engineering Senior Design Projects
Publisher
Utah State University
Location
Logan, UT
Publication Date
12-10-2018
Abstract
GE Healthcare specializes in providing optimized medium for companies culturing cells in bioreactors for pharmaceutical purposes. Small scale testing, typically in shaker flasks, is a crucial part of this process, but scaling between these and larger impeller driven reactors has proven difficult in the past.
This study sought to develop a relationship between shaker flask bioreactors and a micro-bioreactor setup called the ambr® system. Important scale-up parameters such as oxygen transfer rate, 𝑘L𝑎, and energy dissipation rate, 𝜀𝑎, were calculated and used to compare the two systems. The following equations were taken from literature [2],[3]:
Recommended Citation
Daniel, Joshua; Ellsworth, Zachary; and Lunt, Makali, "Stirred, Not Shaken—Considerations for Improved Mammalian Cell Culture Scale-Up" (2018). Biological Engineering. Paper 21.
https://digitalcommons.usu.edu/bioengr_srdesign/21