Document Type

Article

Journal/Book Title/Conference

Journal of Experimental Biology

Volume

224

Issue

9

Publisher

The Company of Biologists Ltd.

Publication Date

5-4-2021

Award Number

Division of Integrative Organismal Systems (IOS) 1752908

Funder

Division of Integrative Organismal Systems (IOS)

First Page

1

Last Page

14

Abstract

There is nothing like a pandemic to get the world thinking about how infectious diseases affect individual behavior. In this respect, sick animals can behave in ways that are dramatically different from healthy animals: altered social interactions and changes to patterns of eating and drinking are all hallmarks of sickness. As a result, behavioral changes associated with inflammatory responses (i.e. sickness behaviors) have important implications for disease spread by affecting contacts with others and with common resources, including water and/or sleeping sites. In this Review, we summarize the behavioral modifications, including changes to thermoregulatory behaviors, known to occur in vertebrates during infection, with an emphasis on non-mammalian taxa, which have historically received less attention. We then outline and discuss our current understanding of the changes in physiology associated with the production of these behaviors and highlight areas where more research is needed, including an exploration of individual and sex differences in the acute phase response and a greater understanding of the ecophysiological implications of sickness behaviors for disease at the population level.

Available for download on Wednesday, May 04, 2022

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