Determination of Ozonation Rate Constants for Lincomycin and Spectinomycin
Document Type
Article
Journal/Book Title/Conference
Ozone Science and Engineering
Volume
26
Publication Date
2004
First Page
1
Last Page
13
Abstract
Recent occurrences of pharmaceutical antibiotics in surface water, drinking water, and wastewater systems have gained significant attention due to their potential threats to human health. This study determined the absolute second-order rate constants of ozone with two amine-based antibiotics, namely, lincomycin and spectinomycin, using the stopped-flow technique under controlled ionic strength, buffer, and temperature. Results indicate that ozone reacts quickly with the selected antibiotics, and the reaction rate significantly depends on solution pH. For lincomycin, ozone attacks its free amine group and sulfur group with absolute rate constants of 2.76 × 106 M−1·s−1 (for neutral form) and 3.26 × 105 M−1·s−1 (for monoprotonated form), respectively. For spectinomycin, ozone attacks two free amine groups with absolute rate constants of 1.27 × 106 M−1·s−1 (for neutral form) and 3.30 × 105 M−1·s−1 (for monoprotonated form), respectively. These rate constants have been corrected to zero ionic strength. Protonated amine is nonreactive toward ozone. Model prediction indicates that lincomycin and spectinomycin can be effectively transformed by ozonation processes around neutral pH.
Recommended Citation
Qiang, Z., Adams, C., Surampalli, R. (2004) “Determination of Ozonation Rate Constants for Lincomycin and Spectinomycin,” Ozone Science and Engineering, 26, 1- 13.
