Synthesis of kurasoin B analogs

Authors

J. R. Nielson
Michael A. Christiansen, Utah State UniversityFollow
M. B. Andrus

Document Type

Poster

Journal/Book Title/Conference

Synthesis of kurasoin B analogs

Publication Date

4-2009

Abstract

Kurasoin B (1), isolated in 1996 by Uchida et al, selectively inhibits Farnesyltransferase (FTase), an enzyme responsible for activating human RAS proteins (ref. 1). When RAS proteins are mutated and then activated, they contribute 20 to 30 percent of all human tumors, including those of the pancreas, colon, small intestine, lung, prostate, liver, skin, and thyroid, as well as multiple myeloma and a number of leukemias (ref. 2). Kurasoin B, therefore, has great potential as a cancer drug lead.

Comments

Abstracts of Papers, 236th ACS National Meeting, Salt Lake City, UT, United States, April 22-26, 2009. Poster.

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Recommended Citation

Nielson, J. R.; Christiansen, M. A.; Andrus, M. B. “Synthesis of kurasoin B analogs.” Abstracts of Papers, 236th ACS National Meeting, Salt Lake City, UT, United States, April 22-26, 2009. Poster.