Document Type
Poster
Journal/Book Title/Conference
Phase-transfer catalyzed synthesis of the Soy isoflavanoid S-Equol
Publication Date
4-2009
Abstract
S-Equol is an isoflavanoid metabolized from the isoflavone daidzein by intestinal bacteria. Only 30-50 percent of all individuals possess bacteria that produce S-Equol. Recent data supports the compound’s pharmaceutical potential for treating prostate cancer and post-menopausal estrogen deficiency (ref. 1). Because the compound is only minutely available from natural sources, an affordable asymmetric total synthesis would be necessary to generate sufficient quantities for expanded research. Only one asymmetric total synthesis of S-Equol has been reported to date, using a chiral auxiliary to give product in a 10 percent yield over 6 steps (ref. 2). It is our goal to develop an improved asymmetric synthesis of S-Equol, and thereby obtain sufficient quantities for biological testing.
Recommended Citation
Butler, A. W.; Calvert, A. L. Christiansen, M. A.; Andrus, M. B. “Phase-transfer catalyzed synthesis of the Soy isoflavanoid S-Equol.” Abstracts of Papers, 236th ACS National Meeting, Salt Lake City, UT, United States, April 22-26, 2009. Poster.
Comments
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