Designed Supramolecular Filamentous Peptides: Balance of Nanostructure, Cytotoxicity and Antimicrobial Activity

Authors

Dawei Xu, Clarkson University
Linhai Jiang, Clarkson University
Anju Singh, Trudeau Institute
Derek Dustin, Clarkson University
Miao Yang, Clarkson University
Ling Liu, Utah State University
Reidar Lund, University of Oslo
Timothy J. Sellati, Trudeau Institute
He Dong, Clarkson UniversityFollow

Document Type

Article

Journal/Book Title

Chemical Communications

Publication Date

11-26-2014

Publisher

Royal Society of Chemistry

Volume

51

Issue

7

Abstract

This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy.

Recommended Citation

Xu, Dawei; Jiang, Linhai; Singh, Anju; Dustin, Derek; Yang, Miao; Liu, Ling; Lund, Reidar; Sellati, Timothy J.; and Dong, He, "Designed Supramolecular Filamentous Peptides: Balance of Nanostructure, Cytotoxicity and Antimicrobial Activity" (2014). Chemistry and Biochemistry Faculty Publications. Paper 626.
https://digitalcommons.usu.edu/chem_facpub/626