Combination of Solid Phase and Solution Phase Synthesis of Oligosaccharides Using Sonication

Document Type

Article

Journal/Book Title

Tetrahedron Letters

Publication Date

8-1-2010

Publisher

Elsevier

Volume

51

Issue

33

First Page

4323

Last Page

4327

Abstract

An approach that combines solid phase and solution phase synthesis of oligosaccharides via the assistance of sonication has been developed. By employing the traceless linker, the designed oligosaccharides can be obtained in pure form and, more importantly, ready for incorporation to aglycons of interest via ‘Click’ chemistry or amide linkage. The overall strategy will facilitate the studies of roles of carbohydrates in bioactive compounds.

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