Document Type

Article

Journal/Book Title

Molecules

Publication Date

3-30-2019

Publisher

MDPI

Award Number

NIH 1R15GM124596-01; American Heart Association 18PRE34030099; Utah State University Office of Research and Graduate Studies PDRF Fellowship

Funder

NIH; American Heart Association; Utah State University Office of Research and Graduate Studies

Volume

24

Issue

7

First Page

1

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Last Page

26

Abstract

Carbon monoxide-releasing molecules (CORMs) that enable the delivery of controlled amounts of CO are of strong current interest for applications in biological systems. In this review, we examine the various conditions under which CO is released from 3-hydroxyflavones and 3-hydroxy-4-oxoquinolines to advance the understanding of how these molecules, or derivatives thereof, may be developed as CORMs. Enzymatic pathways from quercetin dioxygenases and 3-hydroxy-4-oxoquinoline dioxygenases leading to CO release are examined, along with model systems for these enzymes. Base-catalyzed and non-redox-metal promoted CO release, as well as UV and visible light-driven CO release from 3-hydroxyflavones and 3-hydroxy-4-oxoquinolines, are summarized. The visible light-induced CO release reactivity of recently developed extended 3-hydroxyflavones and a 3-hydroxybenzo[g]quinolone, and their uses as intracellular CORMs, are discussed. Overall, this review provides insight into the chemical factors that affect the thermal and photochemical dioxygenase-type CO release reactions of these heterocyclic compounds.

Included in

Chemistry Commons

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