Tracking CO Release in Cells via the Luminescence of Donor Molecules and/or their By‐Products

Document Type

Article

Journal/Book Title

Israel Journal of Chemistry

Publication Date

2-11-2019

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Award Number

NIH 1R15GM124596-01

Funder

NIH

Volume

59

Issue

5

First Page

339

Last Page

350

Abstract

Carbon monoxide (CO) is a bioactive signalling molecule that is produced endogenously via the breakdown of heme. Beneficial health effects associated with the delivery of CO gas have spurred the development of CO‐releasing molecules (CORMs) that can be used to provide specific amounts of the gas. In addition to their potential use as therapeutics, CORMs are needed to provide insight into the biological targets of CO. In this regard, light‐activated CO‐releasing molecules (photoCORMs), are valuable for examining the effects of localized CO release.

Herein we examine luminescent CORMs and photoCORMs that have been reported for tracking CO delivery in cells. A variety of motifs are available that exhibit differing luminescence properties and cover a wide range of wavelengths. Trackable CO donors have been successfully applied to targeting CO delivery to mitochondria, thus demonstrating the feasibility of using such molecules in detailed investigations of the biological roles of CO.

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