Author ORCID Identifier
Wiktor Zierkiewicz https://orcid.org/0000-0002-4038-5959
Mariusz Michalczyk https://orcid.org/0000-0002-6495-6963
Steve Scheiner https://orcid.org/0000-0003-0793-0369
NSF, Division of Chemistry (CHE) 1954310
NSF, Division of Chemistry (CHE)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Over the last years, scientific interest in noncovalent interactions based on the presence of electron-depleted regions called σ-holes or π-holes has markedly accelerated. Their high directionality and strength, comparable to hydrogen bonds, has been documented in many fields of modern chemistry. The current review gathers and digests recent results concerning these bonds, with a focus on those systems where both σ and π-holes are present on the same molecule. The underlying principles guiding the bonding in both sorts of interactions are discussed, and the trends that emerge from recent work offer a guide as to how one might design systems that allow multiple noncovalent bonds to occur simultaneously, or that prefer one bond type over another.
Zierkiewicz, W.; Michalczyk, M.; Scheiner, S. Noncovalent Bonds through Sigma and Pi-Hole Located on the Same Molecule. Guiding Principles and Comparisons. Molecules 2021, 26, 1740. https://doi.org/10.3390/molecules26061740