Date of Award:
5-2009
Document Type:
Thesis
Degree Name:
Master of Science (MS)
Department:
Chemistry and Biochemistry
Department name when degree awarded
Chemistry
Committee Chair(s)
Tom Chang
Committee
Tom Chang
Committee
Alvan Hengge
Committee
Philip Silva
Abstract
In this study, we investigated the potential applications of carbohydrates in the development of new antibiotics. To tackle the problem of multidrug-resistant variants of M. tuberculosis (MDR-TB), we investigated the biosynthesis pathways of trehalose, which has contributed to significant drug resistance. Some new methods were developed for the synthesis of potential inhibitors (6-azido-trehalose and 6,6'-diazido-trehalose) that have been designed to imitate the intermediate molecule (trehalose 6-phosphate, TPP) of OtsA-OtsB pathway. At the same time, some new antibacterial agents based on trehalose have been synthesized. Members of the 1,2,3-triazole family have shown interesting biological properties. Steroid derivatives have been developed in antibiotics area. Therefore click reaction was utilized to build a 1,2,3-triazole ring and combine cholesterol with different carbohydrate moieties. A series of new compounds has been synthesized and their bioactivities have been tested.
Checksum
09c4b04cc0af4e422d097ba57c9ffce5
Recommended Citation
Liang, Yi, "Carbohydrate Derivatives in Antibiotics Research" (2009). All Graduate Theses and Dissertations, Spring 1920 to Summer 2023. 298.
https://digitalcommons.usu.edu/etd/298
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