Date of Award:
5-2016
Document Type:
Dissertation
Degree Name:
Doctor of Philosophy (PhD)
Department:
Chemistry and Biochemistry
Committee Chair(s)
Cheng-Wei Tom Chang
Committee
Cheng-Wei Tom Chang
Committee
Alvan C. Hengge
Committee
Bradley S. Davidson
Committee
Robert S. Brown
Committee
Jon Y. Takemoto
Abstract
The first three projects involve the synthesis and the mode of action study of 1,4-naphthoquinone based anticancer agents. These anticancer agents are highly potent against a wide range of cancer cell lines. These compounds showed ~8-fold selectivity towards the lung cancer cell line than the normal cell line. We also studied the mode of action and observed that generation of reactive oxygen species is the primary mode of action.
The final project involves the synthesis of multi-cationic antimicrobial agents. These compounds are active against both bacteria and fungi. These compounds are very easy to synthesize and can be scaled up if large quantities are needed.
Checksum
4f2319f2656c5e5bcf510e4c723bee56
Recommended Citation
Shrestha, Jaya P., "Synthesis, Structure-Activity Relationship Study, and Mode of Action Study of 1,4-Naphthoquinone Based Anticancer and Antimicrobial Agents" (2016). All Graduate Theses and Dissertations, Spring 1920 to Summer 2023. 4925.
https://digitalcommons.usu.edu/etd/4925
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