Date of Award:

5-2016

Document Type:

Dissertation

Degree Name:

Doctor of Philosophy (PhD)

Department:

Chemistry and Biochemistry

Committee Chair(s)

Steve Scheiner

Committee

Steve Scheiner

Committee

Yujie Sun

Committee

Alexander I. Boldyrev

Committee

T. -C. Shen

Committee

David Farrelly

Abstract

Like cement bridges one brick to another, noncovalent forces also bridge two or more molecules together to form a molecular crystal or molecular cluster. Although weaker than the covalent bond, the existence of noncovalent forces can be seen everywhere from liquid water to construction of complex biomolecules like DNA, RNA, proteins etc. An introduction of suitable charge; positive or negative, on the binding units can increase the strength of noncovalent interaction by several orders of magnitude. The primary aim of this dissertation is to explore some fundamental properties of such charge assisted noncovalent interactions which will be helpful for the rational design of molecular crystals, drugs, catalysts and many more. Besides that, this dissertation also makes parallel study between H-bond and halogen bonds and contradicts the long time notion that the H-bond is the strongest noncovalent interaction.

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