Date of Award:
5-2020
Document Type:
Dissertation
Degree Name:
Doctor of Philosophy (PhD)
Department:
Biological Engineering
Committee Chair(s)
Anhong Zhou
Committee
Anhong Zhou
Committee
Timothy A. Gilbertson
Committee
Jixun Zhan
Committee
T. C. Shen
Committee
Elizabeth Vargis
Abstract
A biosensor is an analytical device integrating a biological element and a physicochemical transducer that convert a biological response into a measurable signal. The advantages of biosensors include low cost, small size, quick, sensitivity and selectivity greater than the conventional instruments. Biosensors have a wide range of applications ranging from clinical diagnostics through to environmental monitoring, agriculture industry, et al.
The different types of biosensors are classified based on the sensor device as well as the biological material. Biosensors can be broadly classified into (piezoelectric, etc.), electrochemical biosensors (potentiometric, amperometric, etc.), and optical types of biosensors (fiber optics, etc.).
Here, we introduce a novel microfluidics-integrated biosensor platform system that can be flexibly adapted to form individual biosensors for different applications. In this dissertation, we present five examples of different emerging areas with this biosensor system including anti-cancer drug screening, glucose monitoring, heavy metal elements measurement, obesity healthcare, and waterborne pathogen DNA detection. These micro-biosensors have great potential to be further developed to emerging portable sensing devices especially for the uses in the developing and undeveloped world. At the last chapter, Raman spectroscopy applied to assess gestational status and the potential for pregnancy complications is presented and discussed. This technique could significantly benefit animal reproduction.
Checksum
34ba6da70d93fa4797df95b2675f631e
Recommended Citation
Zhang, Han, "Micro-Biosensor Devices for Biochemical Analysis Applications" (2020). All Graduate Theses and Dissertations, Spring 1920 to Summer 2023. 7712.
https://digitalcommons.usu.edu/etd/7712
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