Date of Award:
5-2021
Document Type:
Thesis
Degree Name:
Master of Science (MS)
Department:
Psychology
Committee Chair(s)
Sara Freeman (Committee Chair), Scott Bates (Committee Co-Chair)
Committee
Sara Freeman
Committee
Scott Bates
Committee
Diana Meter
Committee
Sarah Schwartz
Committee
Tyler Renshaw
Abstract
It is unclear if cannabis helps individuals cope with life’s stressors or increases the likelihood of developing stress-related disorders such as depression. Chronic unpredictable stress is a validated model of depression that exposes rodents to a series of frequently-occurring, intermittent stressors over the course of a few weeks. This systematic review and meta-analysis summarizes existing research using rodents on the effects of cannabinoids on stress-coping behaviors and neuroendocrinological measurements in chronic unpredictable stress. Databases were systematically searched for articles that met inclusion criteria, and effect sizes between control chronic unpredictable stress groups and cannabinoid-treated chronic unpredictable stress groups were calculated. A meta-analysis of the 26 included articles indicated that cannabinoids prevent the negative effects of chronic unpredictable stress, suggesting that the development of cannabinoid-based drugs has the potential to treat stress-related disorders such as depression.
Checksum
cfd7664c61bfb79ca3f7eb17dc5ef1ec
Recommended Citation
Reuveni, Noa, "The Effects of Cannabinoids on Stress-Coping Behaviors and Neuroendocrinological Measures in Chronic Unpredictable Stress: A Preclinical Systematic Review and Meta-Analysis" (2021). All Graduate Theses and Dissertations, Spring 1920 to Summer 2023. 8098.
https://digitalcommons.usu.edu/etd/8098
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