Date of Award:
12-2011
Document Type:
Dissertation
Degree Name:
Doctor of Philosophy (PhD)
Department:
Psychology
Committee Chair(s)
JoAnn T. Tschanz
Committee
JoAnn T. Tschanz
Committee
Heidi J. Wengreen
Committee
M. Scott DeBerard
Committee
Christopher D. Corcoran
Committee
Beth E. Foley
Abstract
Alzheimer's disease (AD) has multiple factors that contribute to the disease process. Among these is a state of chronic inflammation that is endured by the brain during the aging process. The use of non-steroidal anti-inflammatory drugs (NSAIDs) decreases the amount of neuroinflammation sustained by the brain, and greater levels of NSAID use have been demonstrated to be associated with decreased probability of developing AD. This study looked at whether greater rates of NSAID use were also associated with decreased rates of cognitive and funtional decline and survival in a population-based sample of persons with AD. Linear mixed models failed to find any association between any NSAID use, duration of use, or timing of use (before or after AD onset) and cognitive and functional outcomes. Cox regression models did not find any association between any NSAID use, NSAID use before or after AD onset, or duration of NSAID use and participant survival. The conclusion of this project is that NSAIDs do not affect AD progression or survival rates of persons with AD. These results are discussed within the scope of the current literature.
Checksum
5b893f8a33d08968444c6630e41aac0f
Recommended Citation
Buckley, Trevor R., "Does Non-Steroidal Anti-Inflammatory Drug (NSAID) Use Affect Dementia Progression and Survival Rates in Alzheimer's Disease? The Cache County Study" (2011). All Graduate Theses and Dissertations, Spring 1920 to Summer 2023. 990.
https://digitalcommons.usu.edu/etd/990
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Comments
This work made publicly available electronically on August 9, 2011.