Leveraging Cobalt Carbene Radical for Sustainable Radical Transformations

Author

Liming Tan, Utah State UniversityFollow

Date of Award:

5-2025

Document Type:

Dissertation

Degree Name:

Doctor of Philosophy (PhD)

Department:

Chemistry and Biochemistry

Committee Chair(s)

Gang Li

Committee

Gang Li

Committee

Alvan Hengge

Committee

Bradley Davidson

Committee

Yunfan Qiu

Committee

Xiongyi Huang

Abstract

Radical chemistry plays a key role in modern science, driving the creation of many new materials, medicines, and industrial products. However, because radicals are so reactive, controlling their behavior—especially in terms of how selectively they form or modify specific molecules—has been a major challenge for chemists. Improved control over radical reactions can lead to cleaner, more sustainable manufacturing processes for everything from medicines to new materials. By reducing waste and making reactions more efficient, the research could lower production costs and environmental impacts. This research explores a novel method for controlling radical reactions using a technique called metalloradical catalysis (MRC). MRC relies on metal complexes (compounds involving metals and other molecules) to direct radical reactions with a high degree of precision. Specifically, this work introduces the use of cobaloxime complexes, which are a type of cobalt-based catalyst, to guide radical reactions. These catalysts offer a promising new way to carry out chemical reactions that are both efficient and selective, making them useful for a variety of applications.

The first part of the research demonstrates how these cobaloxime catalysts can be used to form specific molecular structures that are important in pharmaceuticals. By improving the control over these reactions, we can help develop new medicines more effectively. The second part of the research expands this technique to create other important molecular building blocks, such as cyclopropenes and oxazoles, which are used in drug development and materials science. Finally, the research explores the use of these catalysts for reactions involving silicon-hydrogen bonds, which are relevant to the production of specialty chemicals and advanced materials.

In summary, this work contributes to the growing field of metalloradical catalysis, opening new possibilities for more efficient, sustainable, and cost-effective chemical manufacturing processes that have potential benefits for both industry and society.

Checksum

0737b96904e82000ca11d50c2735a743

Recommended Citation

Tan, Liming, "Leveraging Cobalt Carbene Radical for Sustainable Radical Transformations" (2025). All Graduate Theses and Dissertations, Fall 2023 to Present. 410.
https://digitalcommons.usu.edu/etd2023/410