Date of Award:

12-2025

Document Type:

Dissertation

Degree Name:

Doctor of Philosophy (PhD)

Department:

Chemistry and Biochemistry

Committee Chair(s)

Lisa M. Berreau

Committee

Lisa M. Berreau

Committee

Abby D. Benninghoff

Committee

Alvan C. Hengge

Committee

Cheng-Wei T. Chang

Committee

Nicholas E. Dickenson

Abstract

Although often associated with poisoning, carbon monoxide (CO) is naturally produced in the body and plays a crucial role in cellular function. Scientists are exploring ways to use CO as a therapy, as it can protect healthy cells and even help fight diseases like cancer and Alzheimer’s if delivered in the right amount and at the right location. However, safely controlling CO delivery inside cells remains a challenge. This research focuses on developing specialized molecules that release CO when exposed to light. These molecules, called flavonols, are a class of flavonoids that are naturally occurring nutrients found in fruits and vegetables. Flavonols naturally fluoresce, allowing scientists to track their movement within cells. By making small changes to their structure, these molecules behave differently, affecting how much CO they release, where they go inside the cell, and how they interact with other molecules.

Understanding these factors is essential for designing effective CO-based tools and treatments. The work in this dissertation highlights the potential of CO as a powerful therapeutic agent and emphasizes the need for precise control over its delivery. By refining these targeted CO delivery tools, researchers aim to develop safer, more effective treatments for various diseases and gain further insights into the biological roles of CO.

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