Date of Award:

5-2026

Document Type:

Thesis

Degree Name:

Master of Science (MS)

Department:

Psychology

Committee Chair(s)

Mona Buhusi

Committee

Mona Buhusi

Committee

Timothy Shahan

Committee

Erin Bobeck

Abstract

The endocannabinoid system (ECS) is a modulatory system that helps regulate brain functions, including learning and memory, influencing processes such as latent inhibition (LI). LI refers to the slower association formed when a familiar event is paired with a new outcome, compared to the association of an unfamiliar event. LI is a process that is often disrupted in individuals with schizophrenia and is known as a cognitive symptom. This study aimed to determine whether the drug WIN-55-212-2 (WIN), which interacts with the ECS, influences the process of LI using a fear-conditioned response procedure. The results found no significant interaction among the full sample of mice; however, a significant interaction between the drug and control group was observed in our second batch of mice. The interaction was only expressed among the second batch which included a small sample size, meaning further research with larger sample sizes is needed. These findings could help in the understanding of the ECS and how it could be targeted to alleviate symptoms seen in schizophrenia.

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Additional Files

ThesisDrugNodrug.xlsx (14 kB)

ThesisData2.xlsx (15 kB)

MPC code (1).zip (134 kB)

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