Date of Award:
8-2026
Document Type:
Dissertation
Degree Name:
Doctor of Philosophy (PhD)
Department:
Chemistry and Biochemistry
Committee Chair(s)
Cheng-Wei Tom Chang
Committee
Cheng-Wei Tom Chang
Committee
Gang Li
Committee
Yunfan Qiu
Committee
Yi Rao
Committee
Jixun Zhan
Abstract
Azole are first line drugs used for treatment of most fungal infection. Resistance towards azole based drugs are rapidly increasing. Chemical modification of kanamycin creates promising class of antifungal compounds against both human and crop pathogenic fungi. Based on the structure of commonly available azole antifungals, a library of kanamycin-azole hybrids are synthesized, and their antifungal activities are studied. The lead hybrids are active against resistant C. albicans, C. tropicalis and C. neoformans strains.
Early and accurate diagnosis is crucial for timely and effective treatment of fungal infections. Fluorescence based small molecules has the potential for rapid detection by enabling real-time imaging and quantification of fungal cells. A library of fluorescent kanamycin probe are synthesized and tested against various fungal strains. Strain dependent relative fluorescence intensity and unique fluorescence profile were obtained from the synthesized probes.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Recommended Citation
Poudyal, Naveena, "Synthesis, Bioactivity, and Diagnostic Application Study of Aminoglycoside Kanamycin A Derivatives With Azoles and Fluorophores" (2026). All Graduate Theses and Dissertations, Fall 2023 to Present. 851.
https://digitalcommons.usu.edu/etd2023/851
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